AntiViral Research Center In the Department of Medicine
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Current Studies

The AVRC is currently researching:



  • REPRIEVE: Whether a daily dose of pitavastatin (i.e. a cholesterol-lowering medication) lowers the risk of heart-related disease among people living with HIV.
  • KICK & KILL: One strategy on the pathway to possibly curing HIV by activating hidden HIV in the body using an investigational oral toll-like receptor 7 (TLR7) agonist.
  • HAND: Whether adding maraviroc and/or dolutegravir to a stable ARV regimen will improve one's ability to concentrate, remember, solve problems and make decisions.
  • RUXOLITINIB: Studying this drug's effect on inflammation in HIV.
  • PERTURB: Perturbing the HIV reservoir with immune stimulation, using the flu and pneumonia vaccines.
  • ART INTERRUPTION: Collecting info about what happens and the safety of when people pause, or temporarily stop taking, ART, and to collect blood samples from these people at frequent intervals.
  • IAVI T001: The safety, tolerability, pharmacokinetics and antiviral efficacy of the PGT121 monoclonal antibody for HIV prevention and therapy (coming soon).


Pre-Exposure Prophylaxis or PrEP (for HIV-negative individuals)

  • AEGiS: HIV prevention methods with HIV-negative cisgender women using pre-exposure prophylaxis (PrEP) and text messaging.
  • DIGITAL ADHERENCE: A novel wireless ingestible sensor system for measurement of medication adherence in HIV prevention for men and women.
  • DISCOVER: The safety and efficacy of Descovy (F/TAF) for PrEP in men and transgender women who have sex with men and are at risk of HIV-1 infection.
  • TRANSGENDER PrEP STUDIES: Studying linkage to services and PrEP adherence in transgender and gender non-conforming individuals.


Women's Reproductive Health (for HIV-negative individuals)

  • LACTIN-V: Study for women of a probiotic vaginal powder, made up of naturally-occurring Lactobacilli, that may prevent the occurrence of bacterial vaginosis or BV.


To learn more about these and other current clinical trials, please call us at (619) 543-8080 and ask for the Screening Coordinator.

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